Projects
Current projects
2022 bis 2027
EU - HORIZONT 2020
MEDICODE - The Medial Frontal Cortex in Cognitive Control and Decision Making: Anatomy, Connectivity, Representations, Causal Contributions
THE ROLE OF THE MEDIAL FRONTAL CORTEX IN COGNITIVE CONTROL AND DECISION-MAKING: ANATOMY, CONNECTIONS, REPRESENTATIONS, CAUSALITY, Using cognitive control, people flexibly adapt their behaviour to achieve their goals of action in a changing world. Despite intensive research, there is still no overarching understanding of the mechanisms of cognitive control and its underlying main structure, the posterior medial frontal cortex (pMFC). This is due to the insufficient consideration of the neuroanatomy of the pMFC, its subregions and individual variability, the low sensitivity of group studies, the scarcity of causal evidence in humans, and the use of diverse research methods and paradigms in heterogeneous studies, which makes it difficult to differentiate general principles of cognitive control from study-specific idiosyncrasies. The project aims to solve these problems with two completely new approaches:, A) So-called dense sampling, the comprehensive collection of behavioural, imaging, EEG, eye movement and peripheral physiological data in multiple studies of the same subject as they perform cognitive control demanding tasks, allows variables of cognitive control to be quantified directly or via computer modelling. Multivariate analysis procedures are used to identify general as well as task- and modality-specific representations of these variables and to create a functional mapping of the subregions of the pMFC. The basic idea is that general principles of cognitive control over tasks and context should generalise and always be represented in a similar way., B) The new non-invasive brain stimulation with transcranial focused ultrasound (tFUS) allows influencing neuronal activity with unprecedented spatial resolution. In combination with EEG and imaging, tFUS will reveal the necessity of sub-areas of the pMFC and some sub-cortical network partners for cognitive control., In the medium term, this project will open new avenues for studying individual differences and pathological changes in cognitive control.
2021 bis 2025
EU - HORIZONT 2020
PETAL - Positron Emission Tomography for Agriculture and Life
Um die Ernährungssicherheit zu garantieren, muss die Getreideproduktion dem Bedarf der wachsenden Bevölkerung und der Nachfrage nach Futtermitteln und Biotreibstoffen angepasst sein. Eine der derzeitigen Herausforderungen liegt im Klimawandel. Er verursacht im Getreide abiotischen und biotischen Stress, was sich auf Wachstum und Ertrag auswirkt. Mithilfe von Positronen-Emissions-Tomografie wird das EU-finanzierte Projekt PETAL frühe Veränderungen im CO2-Stoffwechsel und Wassertransport im Weizen messen, die von Stress verursacht werden. Die im Projekt entstehenden einzigartigen Datensätze werden analysiert und daraus neue messbare Größen bestimmt, die sich in frühen Phasen der Pflanzenentwicklung aufgrund von Stress verändern. Anschließend soll daraus eine Plattform entwickelt werden, die der Landwirtschaft Dienste für eine frühzeitige Analyse des Weizenwachstums bietet.
2021 bis 2024
EU - HORIZONT 2020
Horizont 2020, Marie S. Curie Individual Fellowships
Das Ziel dieses Projekts ist es, einen neuartigen Rahmen für die rechnerisch effiziente und genaue Simulation von Zweiphasenströmen bereitzustellen, indem die Reihenfolge der Darstellung der Schnittstelle in dem geometrischen VOF-Verfahren von linear bis quadratisch erhöht wird. Dies ermöglicht einen genauen Transport von dritter Ordnung, und eine genaue genaue Schätzung der an der Grenzfläche wirkenden Oberflächenspannungskraft, wodurch Fehler auf eine Weise reduziert wird, die bisher nicht erreicht wurde. Darüber hinaus werden diese Schemata entwickelt, so dass sie auf komplexe Domänen angewendet werden können, was ebenfalls eine Begrenzung vorhandener Verfahren ist, die typischerweise nur in der Lage sind, zweiphasige Flüsse in rechteckigen Strömungsdomänen genau zu simulieren. Das Ergebnis der vorgeschlagenen Forschung ist zweifach. Erstens erhöht die Reihenfolge der Genauigkeit der vorherrschenden zweiphasigen Durchflussmodelliermethode - das VOF-Verfahren - ergibt genauere Simulationsergebnisse. Zweitens erlaubt die vorgeschlagene Arbeit auch die Berücksichtigung komplexer, realistischer Flussdomänen.
2020 bis 2024
EU - HORIZONT 2020
SINFONIA -Radiation risk appraisal for detrimental effects from medical exposure during management of patients with lymphoma or brain tumour
The overall objective of the 4-year SINFONIA project is to develop novel research methodologies and tools that will provide a comprehensive appraisal of the risk for detrimental effects to patients, workers, the public and the environment from radiation exposure during management of patients suspected or diagnosed with lymphoma and brain tumours., SINFONIA will develop novel tools and methodologies that will be demonstrated on two suitable clinical examples i.e. lymphoma and brain tumours. However, SINFONIA research outcomes are not confined to the two specific types of diseases. Some of the procedures performed on lymphoma and brain tumour patients are also carried out on patients with other diseases and SINFONIA radiation dose and risk appraisal methods developed for these two groups of patients will be applicable to other diseases
2020 bis 2023
EU - HORIZONT 2020
AUGMENTED COOPERATION IN EDUCATION AND TRAINING IN NUCLEAR AND RADIOCHEMISTRY (A-CINCH)
Expertise in nuclear and radiochemistry (NRC) is of strategic relevance in the nuclear energy sector and in many vital applications. The need for radiochemistry expertise will even increase as the focus shifts from safe nuclear power plant operation to decontamination and decommissioning, waste management and environmental monitoring. The non-energy fields of NRC applications are even much broader ranging from life sciences - radiopharmaceuticals, radiological diagnostics and therapy - through dating in geology and archaeology, (nuclear) forensics and safeguards operations, to radiation protection and radioecology. The A-CINCH project primarily addresses the loss of the young generation's interest for nuclear knowledge by focusing on secondary / high school students and teachers and involving them by the "Learn through Play” concept. This will be achieved by bringing advanced educational techniques such as state-of-the- art 3D virtual reality NRC laboratory, Massive Open Online Courses, RoboLab distance operated robotic experiments, Interactive Screen Experiments, NucWik database of teaching materials, or Flipped Classroom, into the NRC education. All the new and existing tools wrapped-up around the A-CINCH HUB - a user-friendly and easy-to-navigate single point of access - will contribute increasing the number of students and trainees in the field of nuclear and radiochemistry. Nuclear awareness will be further increased by the High School Teaching Package, Summer Schools for high school students, Teach the Teacher package and many others. Additionally, successful educational and training tools from previous projects will be continued and further developed. Networking is an important part of the project, facilitated by having ENEN as one of the partners and by having structural links with other Euratom projects, the EuChemS, the NRC-Network as well as by additional links with other end users and stakeholders including the high schools.
Completed projects
2020 bis 2023
EU - HORIZONT 2020
EURAMED rocc-n-roll - EURopeAn MEDical application and Radiation prOteCtion Concept: strategic research agenda aNd ROadmap interLinking to heaLth and digitisation aspects
Radiation protection in medical applications is well established throughout Europe, however still facing challenges like large differences in procedures between countries, but even within a country or even within a hospital. In addition, new promising approaches like new technologies as e.g. artificial intelligence or personalized medicine approaches need to be investigated regarding their potential for medical radiation protection. The European Alliance for Medical Radiation Protection Research (EURAMED) platform has been found to promote such research in the EC research programme . Together with five other platforms research in the field of radiation protection is promoted basically in the EURATOM framework. Acknowledging the importance of medical applications as the largest man-made source of exposure and the great possibilities of applying ionizing radiation in medicine the EURATOM programme has launched a call for a coordination and support action to develop a strategic research agenda (SRA) on medical applications of ionizing radiation in general allowing to improve links to other programs like HEALTH or DIGITALIZATION., A consortium called EURAMED rocc-n-roll has been put together to fulfil the task of developing such an SRA partially based on the existing EURAMED SRA on medical radiation protection. In addition it will also develop a roadmap describing how this research agenda can be implemented. An interlink document showing the potential distributions of the different European research programmes to such defined approaches will also be developed. All these documents need to be derived based on a broad consensus of all stakeholders especially also including the patients’ perspective. Therefore, EURAMED rocc-n-roll is based on a series of workshops and writing panels. The workshops will allow contributions by interested stakeholders in person or through members of the consortium., OvGU is serving as the scientific coordinator of the project.
2020 bis 2023
EU - HORIZONT 2020
UNITI - Unification of Treatments and Interventions for Tinnitus Patients
WE STAND UNIT(I)ED AGAINST TINNITUS!, Tinnitus is the perception of a phantom sound and the patient s reaction to it. Although much progress has been made, tinnitus remains a scientific and clinical enigma of high prevalence and high economic burden. It affects more than 10% of the general population, whereas 1% of the population considers tinnitus their major health issue. Recent cohort studies show that tinnitus prevalence tends to increase over time and with older age. Assuming that there is no cure to be found, the prevalence estimates in Europe would double by 2050. A large variety of patient characteristics - including genotyping, aetiology, and phenotyping - are poorly understood, because integrated systems approaches are still missing to correlate patient`s characteristics to predict responses to combinatorial therapies. Although genetic causes of tinnitus have been neglected for decades, recent findings of genetic analysis in specific subgroups (gender and phenotype) have highlighted that bilateral tinnitus in men reached a heritability of 0.68.This heritability is close to autism, schizophrenia and Attention Deficit Hyperactive Disorder (ADHD). There is no current consensus on tinnitus treatment., UNITI s overall aim is to deliver a predictive computational model based on existing and longitudinal data attempting to address the question which treatment approach is optimal for a specific patient based on specific parameters. Clinical, epidemiological, medical, genetic and audiological data, including signals reflecting ear-brain communication, will be analysed from existing databases. Predictive factors for different patient groups will be extracted and their prognostic relevance will be tested in a randomized controlled trial (RCT) in which different groups of patients will undergo a combination of therapies targeting the auditory and central nervous systems.
2021 bis 2022
EU - HORIZONT 2020
PANAPI: Path Aware Networking Application Programming Interface Design and Implementation
The PANAPI (Path Aware Networking API) project will design a sophisticated host-based network-path selection engine on top of the SCION network architecture, and provide it as an open source implementation of the abstract next-generation transport service API currently being drafted in the IETF TAPS Working Group., PANAPI will provide a powerful and extensible framework for automatic path property measurements, path quality evaluation, and optimized path selection, complete with automatic load balancing and failure recovery in a PAN environment, all hidden behind upcoming standard application-facing API abstractions., Our work will empower a large community of developers interested in adding PAN support to their, applications. Incorporation of developer feedback, permissive open source licensing, close collaboration with PAN architects on the PANAPI implementation, and engagement with the IETF community about front end API compatibility and best practices are among our most important priorities.
2018 bis 2022
EU - HORIZONT 2020
Improving neuropsychological functions and clinical course in children and adolescents with ADHD with anodal transcranial direct current stimulation (tDCS) of the prefrontal cortex: a randomized, double-blind, sham-controlled, parallel group trial using an uncertified class IIa device
Kinder und Jugendliche mit einer Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) haben insbesondere in der Schule Schwierigkeiten, sich über einen längeren Zeitraum zu konzentrieren und ihr Verhalten zu steuern. Dabei fällt es ihnen oft schwer Dinge auszublenden, die für die eigentliche Aufgabe nicht wichtig sind. In der vorliegenden klinischen Studie wollen wir untersuchen, ob durch wiederholte, sogenannte transkranielle Gleichstromstimulation (tDCS) über der vorderen Hirnrinde (Frontallappen) Aufmerksamkeits- und Verhaltenskontrolle bedeutsam und langfristig verbessert werden können., Die Wirksamkeit dieser Methode soll dabei mit Hilfe verschiedener Computer-Tests, Fragebögen und eines Elektroenzephalogramms (EEG), das die Hirnaktivität aufzeichnet, überprüft werden. So möchten wir ermitteln, ob die Gleichstromstimulation bei der Behandlung von ADHS hilfreich sein kann, und ob diese Methode für bestimmte Kinder und Jugendliche besonders gut oder nicht gut geeignet ist. Neben dem EEG werden wir auch die Magnetresonanztomographie (MRT) einsetzen, um Veränderungen der Gehirnaktivität durch Stimulation besser zu verstehen und um zu überprüfen, ob Unterschiede in der Gehirnstruktur den Erfolg der Stimulation beeinflussen., Die Studie wird an mehreren Orten in Deutschland (Bielefeld, Frankfurt, Kiel, Magdeburg) und Portugal (Coimbra) durchgeführt; insgesamt sollen ungefähr 200 Kinder und Jugendliche an der Studie teilnehmen. Die Studie wird durch das EU-Rahmenprogramm für Forschung und Innovation Horizont 2020 gefördert und ist Teil eines europäischen Gemeinschaftsprojekts (Grant Agreement Nr. 731827, Sti, mulation in, Ped, iatrics, STIPED, ). Sie wird veranlasst und organisiert durch die Medizinische Fakultät der Otto-von-Guericke Universität Magdeburg, den sogenannten Sponsor dieser Studie (DRKS00012659).
2017 bis 2022
EU - HORIZONT 2020
STIPED: Transcranial brain stimulation as innovative therapy for chronic pediatric neuropsychiatric disorder
Transkranielle Hirnstimulation als innovative Therapie bei ADHS und Autismus, Die transkranielle Gleichstromstimulation (tDCS) wird als innovative, effektive und sichere Alternative in der Behandlung neuropsychiatrischer Erkrankungen bei Erwachsenen bereits erfolgreich eingesetzt. Bei dieser Methode wird die Erregbarkeit bestimmter Gehirnbereiche durch einen schwachen Gleichstrom gezielt beeinflusst. Im vorliegenden Projekt soll erstmals systematisch untersucht werden, ob auch bei Kindern und Jugendlichen mit Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) und Autismus-Spektrum-Störung (ASD) mit Hilfe der transkraniellen Gleichstromstimulation eine Verbesserung kognitiver Funktionen und eine Verringerung klinischer Symptome erreicht werden kann., Im ersten Projektabschnitt wird in drei randomisierten, doppelblinden und sham-kontrollierten Studien bei ADHS und ASD untersucht, welche Veränderungen (Effektstärken) sich durch die Stimulation störungsrelevanter Hirnregionen in zentralen kognitiven Parametern erzielen lassen. In einer Stichprobe gesunder Kinder und Jugendlicher wird weiterhin überprüft, wie sich strukturelle und funktionelle Veränderungen im Lauf der Entwicklung auf die Wirksamkeit von tDCS auswirken. Durch den Einsatz moderner Verfahren der Neurophysiologie, Bildgebung (MRT) und Computersimulation kann untersucht werden, welche individuellen Merkmale Vorhersagen über den Stimulationserfolg erlauben und welche Wirkmechanismen der tDCS sich bei Kindern und Jugendlichen identifizieren lassen. Für viele Familien sind häufige Besuche in einer Klinik oft nur schwer umsetzbar. Deshalb wird im Rahmen des Projekts eine Stimulationseinheit entwickelt, die die sichere und einfache Anwendung der Gleichstrombehandlung durch die Eltern erlaubt. Die Wirksamkeit dieses home-based Behandlungsansatzes wird im letzten Projektabschnitt in einer randomisierten, doppelblinden und sham-kontrollierten Studie untersucht. Weiterhin stehen die ethischen Aspekte der tDCS-Behandlung im Fokus des Projekts. Hierfür werden die Einstellungen, Erwartungen und Bedenken gegenüber transkranieller Elektrostimulation von Kindern und Jugendlichen und ihre Eltern über den gesamten Projektzeitraum erfasst., Das Projekt wird gefördert durch das EU-Rahmenprogramm für Forschung und Innovation Horizont 2020 (Grant Agreement Nr. 731827).
2017 bis 2022
EU - HORIZONT 2020
EUROlinkCAT: Establishing a linked European Cohort of Children with Congenital Anomalies
Europaweite Vernetzung, der, Daten, zu, angeborenen Anomalien, bei, Kindern, Über 130.000 Kinder, die jedes Jahr in Europa geboren werden, haben eine angeborene Fehlbildung (CA). Diese Anomalien oder Fehlbildungen, gehören zwar häufig zu den seltenen Krankheiten, betreffen aber eine große Gruppe und sind somit eine Hauptursache für Säuglingssterblichkeit, Kindheitsmorbidität und -sterblichkeit oder schränken langfristig die Entwicklung und Lebensqualität der betroffenen Familien ein., EUROCAT ist ein etabliertes europäisches Netzwerk von Registern zur Erhebung von angeborenen Anomalien. In dem neuen Projekt EUROlinkCAT wird die EUROCAT-Infrastruktur zur Unterstützung von 21 EUROCAT-Registern in 13 europäischen Ländern genutzt, um deren Daten zu Mortalitäts-, Krankenhausentlassungs-, Rezept- und Bildungsdatenbanken zu verknüpfen. Das zentrale Ergebnis-Verzeichnis (CRR) enthält standardisierte Daten und Analysen über geschätzte 200.000 Kinder mit einer angeborenen Fehlbildung, die von 1995 bis 2014 geboren wurden, bis zum Alter von 10 Jahren. So können Hypothesen über die Gesundheit und Bildung auf EU-Ebene untersucht werden und Diagnose, Prävention, Versorgung und Behandlung für Kinder, betroffen von Anomalien, optimiert werden. Es können im Zusammenhang mit den angeborenen gesundheitlichen Einschränkungen entstehende Entwicklungsdefizite auf europäischer Ebene erkannt und der Entwicklung entgegengewirkt werden., Dieses Registernetzwerk wird unterstützt durch die Nutzung von Social-Media-Plattformen, um mit Familien zu kommunizieren, die in den einzelnen europäischen Regionen leben. Ein neues, nachhaltiges e-Forum, "ConnectEpeople", verbindet diese Familien mit lokalen, nationalen und internationalen Registern und Informationsressourcen. ConnectEpeople wird diese Familien in die Festlegung von Forschungsprioritäten einbeziehen und eine sinnvolle Verbreitung der Ergebnisse sicherstellen., Eine wirtschaftliche Bewertung der Krankenhauskosten im Zusammenhang mit CA wird zur Verfügung gestellt werden. Das CRR und die dazugehörigen Unterlagen, einschließlich Verknüpfungs-, Normungsverfahren und "ConnectEpeople" -Forum, stehen nach EUROlinkCAT zur Verfügung und erleichtern damit künftige Analysen auf lokaler und EU-Ebene., Das Projekt wird gefördert durch das EU-Rahmenprogramm für Forschung und Innovation Horizont 2020 (Grant Agreement Nr. 733001).
2018 bis 2021
EU - HORIZONT 2020
Deep-Learning and HPC to Boost Biomedical Applications for Health (DeepHealth):
Deep-Learning and HPC to Boost Biomedical Applications for Health (DeepHealth), Mit Techniken der artifiziellen Intelligenz werden digitale Supportsysteme entwickelt, die in der klinischen Praxis hilfreich sind. Aufgabe der Klinik für Psychiatrie und Psychotherapie ist es hierbei Studien zur Depression und Demenz durchzuführen und mathematische Modellierungen zur Therapieprädiktion und Prädiktion des Verlaufs durchzuführen
2019 bis 2021
EU - HORIZONT 2020
Deployment and Evaluation of the SCION Secure Internet Architecture on Fed4FIRE+ Testbeds
The main goal of this project is the deployment and evaluation of the SCION network on multiple Fed4FIRE+ testbeds, specifically GEANT GTS, Virtual Wall, Grid5000, and Exogeni. Our SCIONLab infrastructure facilitates the interaction between different deployed SCION networks and services, whereas SCIONLab nodes themselves contribute to the routing within the SCION topology, thus enabling a broad range of novel path-aware applications. To this end, the aim is to interconnect instances of SCION nodes deployed on the different Fed4FIRE+ testbeds among each other as well as with other nodes in the global SCIONLab network such as within DFN and SWITCH and their associated universities OVGU Magdeburg and ETH Zurich.
2019 bis 2021
EU - HORIZONT 2020
RAISING EU PRODUCTIVITY: LESSONS FROM IMPROVED MICRO DATA [MICROPROD]
Labour productivity has slowed down atypically over the last decade or so in the developed world. That means that workers on average are not becoming more productive at quite the same speed as they used to., A similar picture in terms of how labour productivity has slowed down is seen for total factor productivity, i.e. when considering all factors of production, including capital. This is despite technological advancements continuing, and thus offering opportunities for innovation, as well as firms progressively integrating in global value chains, and therefore encouraging competition and gains in efficiency. All of these would suggest improvements in productivity vs. the observed slow down, a paradoxical situation that indicates how poor and incomplete our understanding of the underlying mechanisms at work is., The consequences of this slow down are not innocuous. Contrary to a long-term trend, the current generation expects that future generations may earn less than they do, raising issues about intergenerational transfers and sustainability of welfare systems across generations. At the same time, the benefits of the small productivity improvements are accruing disproportionately to capital over labour. The distribution of wealth is therefore becoming increasingly and very visibly unequal, a fact that causes societal anxiety and unrest. Understanding why this occurs is crucial as we prepare for the post financial crisis era., But what is the root cause of this productivity slow down? Some have argued that part of the answer lies in the way we measure productivity. Outdated methodologies are not in the position to capture how value is created given current technology and therefore vastly underestimates the advancements in productivity. Others are increasingly paying attention to the role of intangible investments, in particular as digital business models are becoming increasingly successful. The argument here is that digital firms have the ability to scale up and produce more without proportional increases in capital. If you are Facebook, you can increase the number of people you reach (and therefore the potential for income) without much additional investment. By contrast, a department store would need to invest in property and people if it wanted to expand its operations. Measured aggregate productivity trends may underestimate future productivity growth when increases in aggregate expenditures disproportionately go to intangible intensive firms. Similarly, tracking productivity changes in real time is made difficult because the returns to intangible investment may be very delayed., Furthermore, there are additional implications of intangible investments that are not fully understood. For example, the difficulty in funding intangible investment through traditional financial channels will have a large impact on firms that rely on tangibles. Even before that, as firms grow with little investments they also have fewer assets that can be used for accessing credit, a fact that may distort lending at an aggregate level. Moreover, the implications of an increased role of intangibles for the organisation of firms into global value chains are also unclear.
2017 bis 2021
EU - HORIZONT 2020
image quality analysis on patient images - EU Projekt MEDIRAD
Medical imaging quality description is today either based on investigating with objective physical mathematical methods images of certain test objects or on subjective reader evaluations. The objective methods can be either based on methods applicable in the Fourier domain or those in the spatial domain. While analytics in the Fourier domain are often quite easy they are often difficult to interpret in terms of provided diagnostic performance. Image quality analysis in the spatial domain is on the other hand typically limited to very specific tasks and complicated to perform. Human reader studies very often result in very different results and are very time consuming. We want to develop a way to characterise patient images based on physical methods to describe image quality so that fast objective measurements correspond to human reader studies. That would allow qulaity assurance on real patient images in the future.
2017 bis 2020
EU - HORIZONT 2020
enhAnced Mobile BiomEtRics (AMBER)
AMBER (enhAnced Mobile BiomEtRics) is a Marie Sklodowska-Curie Innovative Training Network addressing a range of current issues facing biometric solutions on mobile devices. AMBER will comprise ten integrated Marie Sklodowska-Curie Early Stage Researcher (ESR) projects across five EU universities. The Network has the direct support of seven Industrial Partners., The aim of the Network is to collate Europe-wide complementary academic and industrial expertise, train and equip the next generation of researchers to define, investigate and implement solutions, and develop solutions and theory to ensure secure, ubiquitous and efficient authentication whilst protecting privacy of citizens., This project has received funding from the European Union s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 675087.
2016 bis 2020
EU - HORIZONT 2020
CORE - Continuous Resolution and Deracemization of Chiral Compounds by Crystallization
Industries are in need of highly skilled academically trained experts and powerful sets of tools enabling the design, control & prediction of optimized & efficient production process of future high-value products such as chiral pharmaceuticals. The CORE Network will in parallel train 15 ESRs and develop tools, approaches and methods within the area of Continuous Resolution (CORE), the process to obtain enantiopure molecules of chiral compounds., The training objective of the CORE network is to deliver a CORE skills toolbox of knowledge, personal, organizational and impact skills to a core of multi-disciplinary scientists and engineers in the interdisciplinary and cross-sectional field of Continuous Resolution. Each ESR obtains dedicated training through their research project, network events, a webinar course, management involvement and an academic & industrial secondment., The research objective of the CORE Network is to jointly construct a CORE Industrial Toolbox on Continuous Resolution that provides next generation tools, approaches and methods to industry for the development continuous resolution processes. The strongly involved industrial partners will ensure that the CORE Industrial Toolbox fulfils their requirements in the skills gap areas Towards Continuous, Hybrid Resolution and Enabling Resolution., CORE brings together 8 academic and 7 industrial partners resulting in an unparalleled combination of chirality, synthesis and crystallization training and research covering the areas of Chemical Engineering, Chemistry and Applied Physics., This project has received funding from the European Union s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 722456.
2016 bis 2020
EU - HORIZONT 2020
ZIKAlliance Project 53
In dem weltweiten Verbund erforschen Wissenschaftler unterschiedlicher Fachdisziplinen das ZIKA-Virus, welches hauptsächlich über Mücken übertragen wird und bereits in 73 Ländern auftritt. Die ZIKA-Virus-Infektion ist unter anderem Ursache für eine Fehlentwicklung des Gehirns bei Neugeborenen, der sogenannten Mikrozephalie. Bis heute gibt es weder eine Impfung zur Infektionsprävention noch eine spezifische Therapie zur Behandlung der ZIKA-Virus-Infektion., Am Institut für Experimentelle Innere Medizin wird in Kooperation mit dem Max-Planck-Institut für Infektionsbiologie in Berlin ein Verfahren entwickelt, welches es ermöglicht, unter Verwendung der CRISPR/Cas9-Technologie Wirtszellfaktoren zu identifizieren, die für eine ZIKA-Virus-Infektion essentiell sind. Für eine Infektion relevante Wirtszellfaktoren stellen potenzielle Zielstrukturen für eine therapeutische Intervention dar. Die Entwicklung neuer, effizienter Therapieansätze erfordert insbesondere ein fundiertes Verständnis der Regulation und Funktion von Genen während der Infektion. Ziel ist es, Substanzen zu identifizieren, die die Funktion dieser Zielstrukturen spezifisch inhibieren und so die Infektion unterbinden, um neue antivirale Wirkstoffe zu ermitteln.
2018 bis 2020
EU - HORIZONT 2020
Learntech Accelerator (LEA)
Based upon the finding from IMAILE PCP of Innovative STEM/PLE (, www.imaile.eu, ), the project LEARNTECH ACCELERATOR ( LEA) will take a quantum leap from being one standalone project to critical mass of European procurers who will:, Unify LEA procurers network and "Observer Cities ", Implement IMAILE PCP lessons learned as LEA baseline, Recommend a LEARNTECH Demand policy - 2030 to reduce fragmentation of the public sector, Enable increased dialogue between demand/ supply side, Provide transfer of knowledge for the LEARNTECH community ( other procurers, industry, start-ups , end - users, and policy level) in order to remove barriers of innovative procurement, Prepare one PPI ( based upon IMAILE) and one additional future PCP, Speed up awareness rising of innovative procurement including cross sectorial value chains, LEA WP- METHODOLOGY is developed in order to achieve the above mentioned objectives and with focus to "ACCELERATE":, LEA network collaboration ( WP 2), Demand policy recommendations ( WP 3), Dialogue tools/ venues between demand & supply side ( WP 4), Knowledge transfer within the community ( WP5), Awareness rising on EU level ( WP 6), This unified and knowledge based action will result in the LEA ROADMAP 2030 including:, -Critical mass of European procurers of LEARNTECH in collaboration acting first customers, User cases for evidence of cost& time saving/ standardization/ interoperability as results of innovative procurement, 2030 LEARNTECH market foresight and demand policy, Training material/methods/tools for increased competence and dynamic dialogue among LEARNTECH community, One prepared PPI absed upon IMAILE with lessons learned, One addtional prepared PCP identified in LEA Implementation of the LEA project shall contribute to SMART, INCLUSIVE AND SUSTAINABLE DEMAND BASED DEVELOPMENT OF LEARNING TECHNOLOGY
2016 bis 2020
EU - HORIZONT 2020
ADAS&ME : Adaptive Advanced Driver Assistance Systems to support incapacitated drivers and Mitigate Effectively risks through tailor made Human Machine Interaction under automation
ADAS&ME will develop adapted Advanced Driver Assistance Systems that incorporate driver/rider state, situational/environmental context, and adaptive interaction to automatically transfer control between vehicle and driver/rider and thus ensure safer and more efficient road usage. The work is based around 7 Use Cases, covering a large proportion of driving on European roads. Experimental research will be carried out on algorithms for driver state monitoring as well as on Human-Machine-Interaction and automation transitions. Robust detection/prediction algorithms will be developed for driver/rider state monitoring towards different driver states, such as fatigue, sleepiness, stress, inattention and impairing emotions, employing existing and novel sensing technologies, taking into account traffic and weather conditions and personalizing them to individual driver s physiology and driving behavior. Further, the core development includes multimodal and adaptive warning and intervention strategies based on current driver state and severity of scenarios. The final outcome is a driver/rider state monitoring system, integrated within vehicle automation. The system will be validated with a wide pool of drivers/riders under simulated and real road conditions and under different driver/rider states. This challenging task has been undertaken by a multidisciplinary European Consortium of 30 Partners, including an original equipment manufacturer per vehicle type and 7 direct suppliers., The Cognitive Systems Group at Otto-von-Guericke-University will contribute to this consortium by providing analysis of emotional content of acoustic utterances in the car. We will also engage in information fusion of data from various modalities (acoustic, video, and others) and analyzing this data for identifying markers for detecting drowsiness or a loss of control state of the driver, thus contributing to driver assistance in several use cases, such as cars, busses, trucks, and motorcycles.
2016 bis 2019
EU - HORIZONT 2020
EGRET-Plus European Glaucoma Research Training Program-Plus
Glaucoma is the most common age-related neurodegenerative eye-disease in western society and one of the four major blinding eye diseases (cataract, macular degeneration, glaucoma, and diabetic retinopathy). Glaucoma is characterized by a progressive loss of retinal nerve cells. The early changes are often unnoticed by the patient. If untreated or detected too late, glaucoma will end up in blindness, yielding a profound loss of quality of life for the individual and major costs to society. In Europe, there are approximately 3 million people with glaucoma. They all need chronic medical care and, despite of that, approximately 15% of them will become blind during their lifetime., Increasing our knowledge on glaucoma and the aging visual system in general has tremendous potential for innovation in glaucoma care and can thus positively impact the future of millions of European citizens : 1) it enables the development of new tools for the early detection of glaucoma; 2) it can inspire the development and implementation of new treatments; 3) contributes to our understanding of the relationships between various neurodegenerative diseases, and 4) contributes to improving healthy aging in general., Given the vast complexity of the disease, we need researchers that are deeply knowledgeable about glaucoma and intimately familiar with the many different techniques required to study all aspects of glaucoma and the aging visual system: from functional test to anatomy, from gene to ganglion cell, from retina to brain. Generally, knowledge, and thus training, is fragmented and researchers that have been broadly trained are only scarcely, if not at all, available at present., To overcome this, EGRET, the European Glaucoma Research Training Program, will aim its efforts at teaching young researchers in how to acquire and apply new quantitative knowledge on the aging visual system in health and disease (specifically glaucoma).
2017 bis 2019
EU - HORIZONT 2020
Stories of Tomorrow - Students Visions on the Future of Space Exploration
The STORIES project aims to contribute to a dynamic future of children's ebooks evolution by a) developing user-friendly interfaces for young students (10-12 years old) to create their own multi-path stories expressing their imagination and creativity and b) by integrating the latest AR, VR and 3D printing technologies to visualize their stories in numerous innovative ways. In the heart of this intervention lies the vision for integrated curricula and deeper learning outcomes. The project will offer these innovations through a single environment, the STORIES Storytelling Platform which will be the place for students artistic expression and scientific inquiry at the same time. The creations of the students (paintings, models, dioramas and constructions, 3D objects and landscapes, animations, science videos and science theater plays) will be captured and integrated in the form of interactive ebooks. The STORIES technical team will design advanced interfaces in which students will be able to augment characters, buildings, greenhouses and different 3D geometrical structures on a tablet or their computer and inspect their work using a mobile device. The outcome of their work will be detected and tracked, and the video stream is augmented with an animated 3D version of the character or the artifact. The platform will be tested in real settings in Germany, Greece, Portugal, France, Finland and Japan, involving 60 teachers and 3000 students (5th and 6th grade). To achieve this, the proposed project is developing a novel cooperation between creative industries and electronic publishing, educational research institutions in the field of STEM, schools and informal learning centers. The consortium includes 15 partners from Europe, USA, Japan and Australia. But STORIES is going beyond that: The consortium will cooperate in the design of the platform and in the development of the story-line mechanism with Eugene (Eugenios) Trivizas, well known writer of children's books.
2017 bis 2019
EU - HORIZONT 2020
PHOSPHOR - Synthesis of Novel Phosphor Sensor Particles for Advanced Flame Diagnostics
Synthesis of Novel Phosphor Sensor Particles for Advanced Flame Diagnostics Phosphors are ceramic materials that emit luminescence following illumination by laser light. Either the colour or the duration of the luminescence depend on the temperature of the material, and so phosphors can be used for remote temperature measurements. Researchers at the Lehrstuhl für Technische Thermodynamik (LTT), Otto-von-Guericke Universität Magdeburg (Prof. Dr.-Ing. Frank Beyrau), Germany, use thermographic phosphors to measure the temperature and velocity of turbulent flows, by seeding nano- to micrometre-size phosphor particles into the gas or liquid as a flow "tracer"., The primary objective of this research project is to increase the temperature range and sensitivity of this measurement technique via the synthesis of new phosphor particles that are optimised for flow temperature sensing. The research fellow, Dr. Christopher Abram from LTT, will collaborate with the Advanced Combustion and Propulsion Lab (ACP), Princeton University, USA, who have developed innovative synthesis methods capable of producing phosphor particles with specific luminescence properties, size and morphology. At ACP, Dr. Abram will learn how to produce phosphor particles using these advanced methods, and then return to LTT where new materials will be produced and characterised., The project will result in new temperature measurement capabilities for fundamental and applied combustion research, allowing the design of cleaner, fuel-efficient engines in key automotive, aerospace and power generation industries, thereby consuming fewer natural resources and reducing environmental impact. These novel materials will also find use in other remote sensing applications e.g. for biomedicine, as well as in lighting and display technologies, creating further opportunities for collaboration with Princeton University and other research institutions and industry., This project has received funding from the European Union´s Horizon 2020 research and innivation programme under the Marie Skłodowska-Curie grant agreement No 708068.
2017 bis 2019
EU - HORIZONT 2020
Stories of Tomorrow - Students Visions on the Future of Space Exploration
The STORIES project aims to contribute to a dynamic future of childrens ebooks evolution by a) developing user-friendly interfaces for young students (10-12 years old) to create their own multi-path stories expressing their imagination and creativity and b) by integrating the latest AR, VR and 3D printing technologies to visualize their stories in numerous innovative ways. In the heart of this intervention lies the vision for integrated curricula and deeper learning outcomes. The project will offer these innovations through a single environment, the STORIES Storytelling Platform which will be the place for students artistic expression and scientific inquiry at the same time. The creations of the students (paintings, models, dioramas and constructions, 3D objects and landscapes, animations, science videos and science theatre plays) will be captured and integrated in the form of interactive ebooks. The STORIES technical team will design advanced interfaces in which students will be able to augment characters, buildings, greenhouses and different 3D geometrical structures on a tablet or their computer and inspect their work using a mobile device. The outcome of their work will be detected and tracked, and the video stream is augmented with an animated 3D version of the character or the artefact. The platform will be tested in real settings in Germany, Greece, Portugal, France, Finland and Japan, involving 60 teachers and 3000 students (5th and 6th grade). To achieve this, the proposed project is developing a novel cooperation between creative industries and electronic publishing, educational research institutions in the field of STEM, schools and informal learning centres. The consortium includes 15 partners from Europe, USA, Japan and Australia. But STORIES is going beyond that: The consortium will cooperate in the design of the platform and in the development of the storyline mechanism with Eugene (Eugenios) Trivizas, well known writer of children's books.
2015 bis 2019
EU - HORIZONT 2020
NextGenVis ITN - Training the Next Generation of European Visual Neuroscientists for the benefit of innovation in health care and high-tech industry - Stability and plasticity of cortical wiring in albinism
This project aims at uncovering the mechanisms of cortical wiring in the face of abnormal visual development. Usually, eye-brain connections are highly stereotypical. However, albinism radically alters the spatial connection patterns due to a malformed optic chiasm, which makes it a powerful model to study plasticity in the human visual system. Astonishingly, although the representations of the left and right side of the world are completely intermixed in the primary visual cortex in albinism, the patients see equally well in both hemifields. High-resolution fMRI at 7 Tesla magnetic field strength will be used to quantify how the altered connections affect cortical structure and function.
2014 bis 2018
EU - HORIZONT 2020
COST Action FA1401: European network on the factors affecting the gastro-intestinal microbial balance and the impact on the health status of pigs (PiGutNet)
The use of antibiotics in pigs is still widespread and is used to control enteric infectious diseases. This practice can spread antibiotic resistance in the agricultural sector and pose a threat to consumer health. PiGutNet will establish the first european network to address this issue, with specialists in all areas of research. the network coordinates databases and designs innovative tools to define the status of enteric eubiosis in pigs. The main outputs are genome/metabolome-wide association studies and the provision of a roadmap to increase pig resistance to Git infections, leading to improved animal health and welfare, consumer protection and competitive advantage for European agriculture.
